Calcium concentration in the myocytes is crucial in cardiac excitation-contraction coupling (the
conversion of an electrical stimulus to a mechanical contraction of the heart cells). This part of the intricate
process can be studied by simulating the calcium dynamics. In this project we consider a model that
combines stochastic transitions among different states of channels and deterministic calcium dynamics and
perform some computer simulations employing MATLAB. Then, we examine whether the model makes
correspondence with empirical results taken from the Cellular Physiology Laboratory of the Cardiovascular
Research Center (CSIC-ICCC)
2014/2015